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Search results for "clofarabine" in Related Substance Name (exact match)
Showing 1 - 3 of 3 results
Status:
US Approved Rx
(2017)
Source:
ANDA205375
(2017)
Source URL:
First approved in 2004
Source:
NDA021673
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Clofarabine is a anti-cancer drug which was approved by FDA for the treatment of pediatric patients with relapsed or refractory acute lymphoblastic leukemia. After crossing the cell membrane the drug is rapidly metabolized by deoxycytidine kinase to diphosphate and triphosphate metabolites and these metabolites reversibly inhibit hRNR by binding to alpha subunit. Also the triphosphate is incorporated to DNA where it acts as a chain terminator.
Status:
Possibly Marketed Outside US
Source:
Octaplasma by Octapharma Pharmazeutika Produktionsges M B H [Canada]
Source URL:
First approved in 2013
Source:
BLA125416
Source URL:
Class:
MIXTURE
